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CBD (Cannabidiol)

What is CBD?

What is CBD (Cannabidiol)?

What is CBD? CBD or cannabidiol is a compound that belongs to the cannabinoid family produced by the cannabis plant. Cannabis is the general name, all hemp and marijuana types fall in this genus. Hemp and marijuana both contain the 113 different cannabinoids, but in different quantities. Marijuana produces a high quantity of  tetrahydrocannabinol (THC) and low cannabidiol (CBD). This is the type of cannabis that will give a psychoactive effect or “high”. Hemp on the other hand has a high concentration of CBD and low THC concentration. Hemp doesn’t contain enough THC for the psychoactive effects and the CBD may have the an opposing effect on anxiety and disordered thinking brought on by THC.

Although further CBD research is needed in order to fully understand the effects and effectiveness in treating certain disorders and ailments, research into CBD and its effects has been limited but has been gaining momentum with its growing interest. CBD products are meant to be therapeutic and should not be used to treat any illness. See a physician for series conditions and see if CBD could be helpful for you.

Endocannabinoid System

The endocannabinoid system is made up of millions of receptors spread throughout the central and peripheral nervous system of mammals. This system is involved in regulating a variety of physiological and cognitive processes including pain-sensation, mood, appetite, sleep, and memory. Cannabinoids such as CBD and THC interact with and around these cannabinoid receptor sites. The effects each cannabinoid have are still being researched as to the degree of effectiveness in treatments.

There are two primary endocannabinoid receptors, CB1 and CB2, and unlike tetrahydrocannabinol (THC), cannabidiol (CBD) doesn’t actually interact with these receptor sites. The interaction between THC and CB1 receptors are thought to be the cause of the “high” effect. CBD does its work near the receptors, but not with them directly. CBD instead inhibits enzymes from breaking down endocannabinoids, leading to a rise in endocannabinoids in the system. Interaction with CB2 receptor is crucial in management of inflammation and pain.

Studies have found that CBD, among other cannabinoids, may also interact with the central nervous system by activating glycine receptors. These receptors are important in reducing chronic inflammatory pain and neuropathic pain. Glycine receptors, when inflamed, stop working and pain increases. CBD reactivates these receptors and decreases pain sensitivity.

Arthritis

Multiple Sclerosis

Chronic pain

Neuropathic pain

Epilepsy

Inflammation

Depression & Anxiety

Stress

AILMENTS

Arthritis CBD

Arthritis

Arthritis is a common degenerative disease that affects almost 1 in 5 Americans, the most common forms being Osteoarthritis and rheumatoid arthritis. Osteoarthritis (OA) is the wearing down of the cartilage between joints. This is brought on by age or cartilage related injuries and results in bones rubbing together making movement painful. Rheumatoid arthritis (RA) is a disease where tissues are attacked by the body’s own immune system, mostly targeting joints such as fingers, wrists, knees, feet, hips and shoulders. RA attacks both the tissue and bone causing pain, swelling and stiffness. Much of the discomfort of arthritis is from the inflammation. Studies have found that CBD has been effective in reducing pain and inflammation related to the disease.

Arthritis CBD Research

Multiple Sclerosis (MS)

Multiple Sclerosis (MS) is an immune-mediated disease that causes the body’s immune system to attack the central nervous system (CNS). The brain, spinal cord and optic nerves make up the CNS. More specifically, the disease attacks myelin, a fatty substance that surrounds and insulates nerve fibers. The immune system sends T-cells, immune response cells,  damaging or destroying the myelin and nerve fiber. When nerve fibers are damaged, messages in the CNS may be changed or stopped. Symptoms of MS vary from person to person depending on severity and sites of attack, but the symptoms are caused by inflammation within the CNS. This is where CBD has potential to help MS sufferers. CBD has shown to have anti-inflammatory and pain-relieving properties. 

Mutiple Sclerosis CBD Research

Chronic Pain

Chronic pain can come from many sources, whether it be illness such as multiple sclerosis and arthritis, or the result of an injury. Studies have shown CBD to be effective as a therapy for chronic pain and inflammation in mice. CBD, unlike pharmaceutical options for pain relief, doesn’t build a tolerance, making it suitable for a long-term and constant issue.

Chronic Pain CBD Research

Neuropathic Pain

Neuropathic pain is the pain experience when damage or disease is affecting the somatosensory nervous system. This is commonly found in people with spinal cord injury, multiple sclerosis, some strokes, and cancer on peripheral nerves. 

Neuropathic Pain CBD Research

Epilepsy

Epilepsy is a neurological disease that is characterized as unpredictable seizures as well as other health problems. A CBD product has received FDA approval in the treatment of two rare kinds of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome. A new drug, Epidiolex which is 99% pure CBD, was found to be effective in reducing the frequency of seizures of patients. This FDA approval shows there is strong enough evidence for CBD to be an effective treatment for two forms of epilepsy. Other CBD studies have shown potential for other forms of epilepsy, but have yet to reach FDA approval.

Epilepsy CBD Research

Inflammation

Inflammation is a very common side effect of many illnesses, conditions, and injuries, generally the body telling that something is wrong. The research into CBD and it’s anti-inflammatory properties are one of the most studied areas of potential CBD effects. Research points to CBD and its interaction with CB2 receptor as the site where an anti-inflammatory and anti-pain effect seems to be occurring.

Inflammation CBD Research

Anxiety CBD

Depression & Anxiety

Millions of Americans suffer from depression and anxiety. While there are pharmaceutical options, they often times have unwanted side effects and other treatments like CBD use are being researched. Studies have shown that in pre-clinical models, facilitation of endocannabinoid neurotransmission evokes both antidepressant and anxiolytic (anti-anxiety) effects.

Depression & Anxiety CBD Research

Stress

Stress is hard to avoid in this day and age, but with a properly functioning endocannabinoid system, stress can be managed just like pain. Endocannabinoid signals have been found in the area responsible for stress hormones, the Hypothalamic-Pituitary-Adrenal (HPA) Axis. What is CBD supposed to do to help with Stress? Research suggests that an increase in cannabinoids increases the release of glucocorticoids, an anti-stress hormone.

Stress CBD Research

Side Effects

  • Drowsiness – It has been reported that some people experience tiredness. This could be due to too large of a dosage and dosage should be re-evaluated. Reactions can vary from person to person, some may be affected by drowsiness more than others and some not at all.
  • Dry Mouth –  Study has shown that CBD interacts with two receptors (CB1 and CB2) in our endocannabinoid system that are present in the salivary glands and are responsible for salvation. The activation of these receptors leads to a decrease in saliva production. Solution to this problem is drink plenty of water.
  • Lower Blood Pressure – Studies have found that large doses of CBD can cause a small drop in blood pressure. This lowering of blood pressure can cause dizziness. If you have prior blood pressure issues consult a physician for advice on CBD for you.

Side Effects CBD Research

Still have questions about CBD? Head over to the FAQ page to see if your answer is there or send us a message.

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